RxLabelGuard provides FDA-sourced drug interaction data via REST API with severity scoring, mechanism details, and evidence citations. Start free — no credit card required.
DrugBank is retiring their free Interaction Checker tool and DDI Checker API on March 25, 2026. Teams relying on this service need to evaluate alternatives before the deadline.
If you're currently using DrugBank for drug interaction checks in your EHR integration, pharmacy software, or clinical decision support system, now is the time to plan your migration.
Read our detailed migration guideSide-by-side feature comparison to help you evaluate your migration.
| Feature | DrugBank | RxLabelGuard |
|---|---|---|
| Data Source | Proprietary curated database | FDA Structured Product Labeling |
| Pricing | Enterprise licensing (contact sales) | Free tier, $20/mo Developer, $99/mo Professional |
| Setup Time | Sales cycle + procurement | Self-service, minutes to first API call |
| Interaction Output | Structured pairs | Structured pairs with severity + evidence citations |
| Drug Resolution | DrugBank IDs | RxNorm (RxCUI), NDC, brand/generic names |
| Evidence Citations | Limited source references | SPL Set ID + label section + text snippet |
| API Format | REST API | REST API (JSON) |
| Free Tier | No | Yes (50 req/month) |
Three steps from drug names to structured interaction data.
Pass drug names, NDC codes, or RxCUI identifiers via our REST API.
Fuzzy name matching normalizes your input to RxCUI, then we fetch the latest FDA label.
Receive interaction pairs with severity, mechanism, recommendations, and FDA evidence citations.
Create an account, generate an API key, and start testing in minutes — no sales calls required.
50 requests/month on the free Sandbox tier. Upgrade to Developer ($20/mo) or Professional ($99/mo) when ready.
Clean JSON endpoints. Straightforward integration into your existing stack.
All interactions link back to official FDA labels with verifiable source references.
Start free. Scale as you grow. No enterprise sales cycle required.
50 requests/month, 1 API key
2,000 requests/month, 5 API keys
20,000 requests/month, unlimited keys
Free tier available. Test with your critical drug pairs today.
Medical Disclaimer: This information is derived from FDA Structured Product Labeling and is provided for informational purposes only. It should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider.