RxLabelGuard delivers FDA-sourced drug interaction data through a REST API with severity scoring, mechanism details, and evidence citations. Transparent pricing starting at $20/month with a 7-day free trial. Self-service signup, no sales call required.
EfficaSafe is a drug and supplement interaction reference. Teams evaluating interaction data sources sometimes compare it with other clinical drug information products when deciding how to add interaction checking to their software.
We have intentionally kept the description of EfficaSafe brief. For authoritative and up-to-date details about EfficaSafe's features, coverage, and pricing, please consult EfficaSafe directly. The rest of this page focuses on what RxLabelGuard provides so you can decide whether a self-service, FDA-sourced interaction API fits your use case.
RxLabelGuard is a focused drug interaction detection API. It resolves drug inputs to standard identifiers, retrieves the latest FDA Structured Product Labeling, and returns structured interaction data with severity scoring and evidence citations. It is built for developers who want to send drug names to an endpoint and receive JSON back, rather than browse a reference interface.
The reasons below describe RxLabelGuard's own capabilities. They are not claims about EfficaSafe -- consult EfficaSafe for details on what it offers.
Create an account, generate an API key, and start querying drug interactions in minutes. There is no sales process to work through before you can begin building and testing.
Plans and request limits are listed publicly: Developer at $20/month and Professional at $99/month. You can budget for a project without requesting a custom quote first.
Every interaction result includes verifiable references drawn from FDA Structured Product Labeling -- the SPL Set ID, label section, and evidence text -- for compliance documentation and clinical audit trails.
Send drug names, NDC codes, or RxCUI identifiers to an endpoint and receive structured JSON with severity, mechanism, and recommendations. The API works with any system that can make HTTP requests.
Interactions are classified across five severity levels -- contraindicated, major, moderate, minor, and unknown -- so you can apply consistent alerting and scoring logic in your own application.
Test your critical drug pairs during a 7-day free trial of the Developer plan before entering payment. This lets you validate coverage for your specific use case up front.
We list what RxLabelGuard provides. For EfficaSafe's current capabilities and pricing, please refer to EfficaSafe directly -- we do not restate them here.
| Feature | EfficaSafe | RxLabelGuard |
|---|---|---|
| Data Source | Refer to EfficaSafe's own documentation | FDA Structured Product Labeling (public, verifiable) |
| Scope | Drug and supplement interaction reference | Focused on drug interaction detection with severity scoring and evidence citations |
| Pricing | See EfficaSafe for current pricing | Developer ($20/mo, 7-day free trial), Professional ($99/mo) |
| Setup Time | Refer to EfficaSafe's own documentation | Self-service: minutes to first API call |
| Free Trial | Refer to EfficaSafe's own documentation | 7-day free trial with full Developer plan access |
| Severity Levels | Refer to EfficaSafe's own documentation | Five levels: contraindicated, major, moderate, minor, unknown |
| Evidence Citations | Refer to EfficaSafe's own documentation | SPL Set ID + FDA label section + evidence text snippet per interaction |
| Drug Resolution | Refer to EfficaSafe's own documentation | RxNorm (RxCUI), NDC codes, brand and generic names |
| Self-Service Signup | Refer to EfficaSafe's own documentation | Yes -- create account, generate API key, start testing immediately |
The "EfficaSafe" column is intentionally left to EfficaSafe's own documentation. We avoid stating specifics we cannot independently verify. RxLabelGuard focuses on drug interaction detection sourced from FDA Structured Product Labeling with evidence citations.
Three steps from drug names to structured interaction data.
Pass drug names, NDC codes, or RxCUI identifiers to our REST API endpoint. We accept brand names, generic names, and common abbreviations.
Your input is normalized to RxCUI via RxNorm fuzzy matching, then we retrieve the latest FDA Structured Product Label for each drug.
Receive interaction pairs with severity level, mechanism of action, clinical recommendations, and FDA evidence citations including SPL Set ID and label section.
Check drug interactions in your language of choice. All responses include severity scoring and FDA evidence citations.
curl -X POST https://jd6095ijga.execute-api.us-east-2.amazonaws.com/v1/interactions/check \
-H "Content-Type: application/json" \
-H "x-api-key: YOUR_API_KEY" \
-d '{
"drugs": ["warfarin", "aspirin"]
}'import requests
response = requests.post(
"https://jd6095ijga.execute-api.us-east-2.amazonaws.com/v1/interactions/check",
headers={
"Content-Type": "application/json",
"x-api-key": "YOUR_API_KEY",
},
json={"drugs": ["warfarin", "aspirin"]},
)
data = response.json()
for interaction in data.get("interactions", []):
print(f"{interaction['severity']}: {interaction['description']}")const response = await fetch(
"https://jd6095ijga.execute-api.us-east-2.amazonaws.com/v1/interactions/check",
{
method: "POST",
headers: {
"Content-Type": "application/json",
"x-api-key": "YOUR_API_KEY",
},
body: JSON.stringify({ drugs: ["warfarin", "aspirin"] }),
}
);
const data = await response.json();
data.interactions.forEach((interaction) => {
console.log(`${interaction.severity}: ${interaction.description}`);
});Teams reach for a focused interaction API when they need to embed drug interaction checking directly into their own software.
Development teams building drug interaction checking into electronic health record systems need an API they can call at the point of prescribing. A self-service API with clear documentation reduces integration time from months to days.
Pharmacy software vendors embedding interaction alerts into their dispensing workflow need programmatic access to interaction data with severity levels and clinical recommendations.
Digital health startups and telehealth platforms need lightweight drug interaction checking that fits within their existing API architecture. A free trial allows prototyping before committing.
Teams building clinical decision support tools need interaction data they can incorporate into their own scoring and alerting logic, not a fixed reference interface.
Start with a free trial. Scale as you grow. Pricing is published, not quote-only.
2,000 requests/month, 5 API keys, 7-day free trial
20,000 requests/month, unlimited keys
Start your free trial and test with your critical drug pairs. No sales call required. Go from sign-up to first API response in minutes.
Already evaluating? Learn more about the free trial
Medical Disclaimer: This information is derived from FDA Structured Product Labeling and is provided for informational purposes only. It should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider. EfficaSafe is a trademark of its respective owner. RxLabelGuard is not affiliated with or endorsed by EfficaSafe.